Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: Solubility of 5-FU determined in different types of oils and surfactants.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques: Solubility

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: 5-FU-DDTC complex formation by Keto-enol mechanism.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques:

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: Distribution of 5-FU-NE is determined by dynamic light scattering techniques (A), zeta potential of 5-FU-NE (B), SEM images (C), and TEM images (D).

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques: Zeta Potential Analyzer

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: DSC-thermograms showed endothermic peaks of castor oil, 5-FU, Transcutol HP, PEG-400, 5-FU-NE, Carbopol and freeze dried optimized-5-FU-NE-Gel.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques:

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: Spectral analysis of ATR of castor oil, 5-FU, Transcutol HP, PEG-400, 5-FU-NE, Carbopol and freeze dried optimized-5-FU-NE-Gel.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques:

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: showed the %age-cumulative-release of 5-FU from 5-FU-NE and 5-FU-NE-Gel when it compared with pure 5-FU-S.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques:

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: showed a comparative ex vivo various skins (cow, goat, & rat) permeation study of 5-FU from 5-FU-NE and 5-FU-NE-Gel.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques: Ex Vivo

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: %Age permeation of 5-FU and their retention of skin in stratum corneum (SC) and viable part of the skin ex-vivo from 5-FU, 5-FU-NE, and 5-FU-NE-Gel nanoformulation.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques: Ex Vivo

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: Mass spectrum of 5-FU-MS-Scan i.e. protonated precursor [M-H] – ions at m / z 129 [A], 5-FU-MSMS-Scan fragmentation transitions i.e. major fragmented product ion at m / z 42 [B], and a chromatogram of UHPLC showing retention time 1.710 min.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques:

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: Mass spectrum of Diethyldithiocarbamate (DDTC)-MS-Scan and Sodium-Diethyldithiocarbamate (DDTC)-MS-Scan showed at protonated precursor [M-H] – ions at m / z 147.27, and 170.21 [A], MS-Scan of complex 5-FU with Diethyldithiocarbamate (DDTC)-MS-Scan and Sodium-Diethyldithiocarbamate (DDTC)-MS-Scan product ion at m / z 277.09 and 300.26 [B], and a UHPLC chromatogram of showing retention time 0.736 and 2.185 min for DDTC chelating agent individual and DDTC–5-FU complex [C].

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques:

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: Fluorescence micrographs of cow- and goat-ear pinna skin and rat skin treated with the formulation 5-FU-S (A) 5-FU-NE (B) 5-FU-NE-Gel (C). Different type of formulations labelled with hydrophilic fluorescence probe (6-carboxyfluorescein) to mark the penetration of the 5-FU to deep skin strata.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques: Fluorescence, Formulation

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: %Age-Cell viability (n = 3, SD, mean) of 5-FU in free 5-FU aqueous solution, control, and optimized-5-FU-NE, and 5-FU-NE-Gel nanoformulation on melanoma cell lines. Optimized–5-FU-NE3 (p < 0.05) and 5-FU-NE3-Gel (p < 0.01) were highly significant than free 5-FU-S.

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques:

Journal: Saudi Journal of Biological Sciences

Article Title: A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin

doi: 10.1016/j.sjbs.2020.02.014

Figure Lengend Snippet: IC50 and % Cytotoxicity of free 5-FU, opt-5-FU-NE, 5-FU-NE-Gel, and control on melanoma cancer cell lines (n = 3).

Article Snippet: 5-Fluorouracil was obtained from Chem-Impex International, Inc. Milli-Q-water purification system (ELGA, Made in UK) was used for purification of water i.e. Milli-Q-water.

Techniques: Concentration Assay